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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIK1 All Species: 38.48
Human Site: Y27 Identified Species: 70.56
UniProt: P57059 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57059 NP_775490.2 783 84902 Y27 K P L R V G F Y D I E R T L G
Chimpanzee Pan troglodytes XP_531484 783 84972 Y27 K P L R V G F Y D I E R T L G
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_544912 898 97147 Y152 K P L R V G F Y D V E R T L G
Cat Felis silvestris
Mouse Mus musculus Q60670 779 85009 Y27 K P L R V G F Y D V E R T L G
Rat Rattus norvegicus Q9R1U5 776 84890 Y27 K P L R V G F Y D V E R T L G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511894 801 88312 Y26 R P L R V G F Y D I E R T L G
Chicken Gallus gallus Q9IA88 798 88848 Y26 R P L R V G F Y D I E R T L G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 Y59 P L A R V G Y Y E M E R T I G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_569972 1398 149888 Y141 E P M R V G F Y D I E R T I G
Honey Bee Apis mellifera XP_397175 718 80391 F28 G T I G K G N F A V V K L A R
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 Y170 Q D V H V G K Y K L L K T I G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671
Baker's Yeast Sacchar. cerevisiae P06782 633 72027
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 69.2 N.A. 81.3 81.6 N.A. 70.4 66.6 N.A. 32 N.A. 28.8 36.5 24.5 N.A.
Protein Similarity: 100 99.6 N.A. 73.6 N.A. 86.2 86.3 N.A. 77 76.6 N.A. 44 N.A. 38 50.9 39.4 N.A.
P-Site Identity: 100 100 N.A. 93.3 N.A. 93.3 93.3 N.A. 93.3 93.3 N.A. 53.3 N.A. 80 6.6 33.3 N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 100 N.A. 80 N.A. 100 33.3 66.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 28.2 27.2 N.A.
Protein Similarity: N.A. N.A. N.A. 41 42.7 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 0 0 0 8 0 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 0 0 0 0 62 0 0 0 0 0 0 % D
% Glu: 8 0 0 0 0 0 0 0 8 0 70 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 62 8 0 0 0 0 0 0 0 % F
% Gly: 8 0 0 8 0 85 0 0 0 0 0 0 0 0 77 % G
% His: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 0 0 0 0 0 39 0 0 0 24 0 % I
% Lys: 39 0 0 0 8 0 8 0 8 0 0 16 0 0 0 % K
% Leu: 0 8 54 0 0 0 0 0 0 8 8 0 8 54 0 % L
% Met: 0 0 8 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % N
% Pro: 8 62 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 16 0 0 70 0 0 0 0 0 0 0 70 0 0 8 % R
% Ser: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 8 0 0 0 0 0 0 0 0 0 0 77 0 0 % T
% Val: 0 0 8 0 77 0 0 0 0 31 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 8 77 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _